Wholesale CBC Isolate is largely believed to be a non-psychoactive derivative of Cannabigerol, the parent compound of all cannabinoids. This Bulk CBC extract is created when cannabichromene carboxylic acid (CBCa) is decarboxylated from cannabigerol acid (CBGa).
Isolated CBC contains nothing just cannabichromene, with no cannabinoids, flavonoids, terpenes, or terpenoids present. By removing all of the secondary cannabis components from the CBC isolate. A product with a concentration of 95–99 percent CBC can be made.
Adding CBC products to your lineup with our CBC Isolate would be a great move. CBC isolate’s potency and purity make it ideal for precise dosing and effective incorporation into other products.
Cannabinoids, such as CBC, are gaining in popularity. As more people learn about the benefits of new cannabinoids, the need for the entire range of cannabinoids, not just CBD, will increase.
Together with cannabidiol (CBD) and tetrahydrocannabinol (THC), cannabichromene (CBC) is one of the most prevalent cannabinoids discovered in the cannabis plant (including hemp flower strains) . Cannabis and hemp strains from all over the world contain CBC. All of the world’s major cannabis producing regions are represented here: Afghanistan, Pakistan, Lebanon, Iran, Turkey, Mexico, Brazil, Costa Rica, Jamaica, and South Africa. Cannabis has the highest concentration of CBC, however hemp also contains trace amounts. Similar to CBD, CBC is non psychoactive and cannot be used to produce intoxication. However, it may improve the brain’s uptake of THC if taken together.
Cannabichromene (CBC): What Are Its Advantages?
Although it is not as common as CBD or THC, cannabichromene can still be found in trace amounts, just like CBG and other minor cannabinoids. This suggests that isolating CBC is a costly endeavour. Generally speaking, a Wholesale CBC Isolate is what is used in studies examining the advantages of Bulk CBC. This means that consuming a hemp strain containing CBC will not provide you with the aforementioned benefits. This doesn’t rule out the possibility of experiencing these advantages individually or in combination with those of other cannabinoids and terpenes.
Reduce Chronic Pain
In 2011, CBC Isolate alleviated osteoarthritis pain. CBC Isolate, like many cannabinoids, has a distinct anti-inflammatory action than NSAIDs.
According to one study, CBC Isolate plus THC had an entourage effect. This had a greater anti-inflammatory effect than either cannabinoid alone.
Researchers investigated Bulk CBC Isolate and paw edema in this study. Edema is reduced by the cannabinoid. The impact occurred in the absence of CB receptors. THC antagonists inhibited its usual action, whereas CBC Isolate did not.
Functions as an Antibacterial and Antifungal
So, why is CBC advantageous? Multiple in vivo and in vitro investigations have shown that CBC can reduce inflammation, kill germs, and inhibit fungal growth. To kill bacteria, scientists tested CBC and found that it was more effective than the common antibiotic streptomycin sulphate against Bacillus subtilis, on par with streptomycin sulphate when tested against Mycobacterium smegmatis, and highly effective against Staphylococcus aureus. Researchers found that whereas CBC had strong antifungal activity against T. mentagrophytes, it only had weak to moderate action against C. albicans and S. cervisiae, two of the most common types of yeast.
Effects on Inflammation and Pain
Cannabichromene’s anti-inflammatory effects are the result of a web of complex cellular interactions. In a nutshell, CBC was found to considerably lower nitrite levels by way of immune cells called macrophages that had been activated. In addition to its effects on endocannabinoid inactivation, CBC may also act via the transient receptor potential ankyrintype 1 (TRPA1, an ion channel on cells that participates in inflammatory signalling). All of these biological systems work together to dampen inflammation. The mice in the study where this mechanism was discovered did not develop colitis.
Multiple intricate interactions between CBC, the CB1 receptor, the CB2 receptor, and THC have been noted by researchers . Like CBD, CBC does not affect the endocannabinoid system through the CB1 or CB2 receptors directly but rather through indirect processes. Furthermore, CBC was found to have analgesic (pain-reducing) properties in a mouse model. Intriguingly, the researchers found that the anti-inflammatory effects of CBC and THC were amplified when administered simultaneously. Scientists also discovered that CBC facilitated the brain’s uptake of THC.
“30 or 100 mg/kg CBC led to considerably higher THC levels in the brain,” write DeLong et al. (2010). However, the effect on THC blood levels was not quite statistically significant (p=0.07). The pharmacological effects of THC at the threshold dose were amplified when combined with the same doses of CBC, which is interesting to note. Because of the entourage effect, the therapeutic effects of Wholesale CBC Isolate can be amplified by the addition of a small amount of THC. Since they frequently co-occur in specific cannabis strains, it stands to reason that they complement each other well.
Exactly what role does cannabichromene play in the effects of cannabis?
We touched on CBC’s anti-inflammatory effects, but how exactly does it affect our systems if it does not act via CB1 or CB2? “CBC has been shown to significantly interact with TRP action channels,” writes Marcu, J. P. (2016). This includes TRPA1, TRPV1-4, and TRPM8. Further, “Bulk CBC can interact with transient receptor potential (TRP) cation channels that impede endocannabinoid inactivation, and stimulate CB2 receptors,” (Russo, E. B., & Marcu, J., 2017). however, it does not appear to have any appreciable effect on CB1 receptors…”
To clarify, “TRP cation channels” refers to channels found in the plasma membrane surrounding cells in animals. These ion channels allow cations to enter the cell. Sodium, calcium, and magnesium are all examples of cations. These cations serve as biological signals, instructing various cellular processes to activate, deactivate, release additional signalling molecules, or take some other action. TRP channels are involved in the transduction that causes CB2 receptor stimulation in response to CBC.
CBC has an effect on the endocannabinoid system since it does not act on cannabinoid receptors directly. It stands to reason that CBC would help with inflammation and pain if it were to positively affect TRP channels, which the endocannabinoid system also does.
Dosage for CBC
The “lethal dose” of CBC is relatively high, although there is no standard or FDA-approved dosage. In studies where CBC was given orally, no deaths occurred even at 3000mg/kg/day . Some of the test animals were killed by that dose when it was injected. However, such a high dose would be prohibitively expensive and impracticable. When compared to the anti-inflammatory drugs phenylbutazone (PBZ) and aspirin, Bulk CBC has a lower toxicity and can be given in higher doses.
Producing CBC: What Goes Into It?
There are cannabinoids in cannabis plants, but they are not “activated” because they are not “decarboxylated.” That means cannabichromene, in its bioavailable form, is found in the cannabinoid acid of a living cannabis plant (CBCa). With the help of the enzyme CBCA synthase, geranyl pyrophosphate and olivetolic acid are converted into CBCa. Over time, or at temperatures exceeding 200 degrees Fahrenheit, CBCa decarboxylates to CBC.
Insights and Reflections
Now that you know how Bulk CBC functions in your body, you may want to pick a high CBC hemp strain rather than the upcoming CBC isolation. This is due to the synergistic nature of cannabis. There are advantages to each one separately, but when left in their original state they can function as Mother Nature intended. No one knows for sure the long-term impacts or overall effectiveness of CBC because there is so little human research on Wholesale CBC Isolate and no clinical trials. Cannabinoids other than THC and CBD are always a fascinating discovery. Cannabichromene and the other cannabinoids and terpenes present in cannabis contribute significantly to the overall effect.